Diversity-oriented synthesis of novel polycyclic scaffolds using polymer-bound reagents |
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| Authors: | García-Cuadrado Domingo Barluenga Sofia Winssinger Nicolas |
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| Institution: | Institut de Science et d'Ingénierie Supramoléculaires, Université Louis Pasteur - 67000, Strasbourg, France. |
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| Abstract: | A concise sequence utilizing a Petasis three component reaction followed by a tandem aza-Cope-Mannich cyclization afforded novel polycyclic heterocycles in good yield; alternative iminium cyclization based on a Pictet-Spengler reaction or aminal formation led to divergent pathways affording skeletal diversity. |
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