DNA Interactions of a Dinuclear Ruthenium(II) Complex Bridged by 1,3-bis(1,10-phenanthroline[5,6-d]imidazol-2-yl)benzene |
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| Authors: | Hui Chao Yi-Xian Yuan Feng Zhou Liang-Nian Ji Jian Zhang |
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| Affiliation: | (1) Department of Chemistry, State Key Laboratory of Optoelectronic Materials and Technologies, The Key Laboratory of Gene Engineering of Ministry of Education, Sun Yat-Sen University, Guangzhou, 510275, China;(2) The Second Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510275, China |
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| Abstract: | A novel dinuclear ruthenium(II) complex [(phen)2Ru(mbpibH2)Ru(phen)2]4+ [phen = 1,10-phenanthroline; mbpibH2 = 1,3-bis(1,10-phenanthroline[5,6-d]imidazol-2-yl)-benzene] has been synthesized and characterized. The DNA-binding behavior of this complex has been studied by spectroscopic and viscosity measurements. Results suggest that the dinuclear ruthenium(II) complex intercalates into DNA base pairs via its bridging moiety. It has also been found that the dinuclear ruthenium(II) complex displays the enantiopreferential DNA-binding after equilibrium dialysis. |
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