Rapid and efficient one-pot synthesis of 1,4-dihydropyridine and polyhydroquinoline derivatives through the Hantzsch four component condensation by zinc oxide |
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Authors: | F Matloubi Moghaddam H Saeidian Z Mirjafary A Sadeghi |
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Institution: | 1. Laboratory of Organic Synthesis and Natural products, Department of Chemistry, Sharif University of Technology, Tehran, Iran, P. O. Box 11155-9516, Tehran, Iran
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Abstract: | A one-pot four-component reaction of aldehydes, ethyl acetoacetate/5,5-dimethyl-1,3-cyclohexanedione, ethyl acetoacetate and ammonium acetate in the presence of 10 mol% of ZnO as a heterogeneous catalyst for the synthesis of corresponding 1,4- dihydropyridine and polyhydroquinoline derivatives via the Hantzsch condensation is described. The present methodology offers several advantages such as simple procedure, excellent yields, and short reaction time. |
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