Oscillatory kinetics of gene expression: Protein conversion and slow mRNA transport |
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Authors: | V P Zhdanov |
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Institution: | 1.Department of Applied Physics,Chalmers University of Technology,G?teborg,Sweden;2.Boreskov Institute of Catalysis,Russian Academy of Sciences,Novosibirsk,Russia |
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Abstract: | The negative feedback between mRNA and regulatory-protein production may result in oscillations in the kinetics of gene expression
if the mRNA-protein interplay includes protein conversion. Using a mean-field kinetic model, we show that such oscillations
can be amplified due to limitations of the mRNA transport between the nucleus and cytoplasm. This effect may be dramatic for
the mRNA population in the nucleus.
The article is published in the original. |
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Keywords: | |
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