|
|||||
|
|
A novel Friedlander-type synthesis of 3-aryl quinolines from 3-oxo-2,3-diaryl-propionaldehydes |
|
| Authors: | Wanrong LuoQiuchao Mu Wenwei QiuTing Liu Fan YangXiaofeng Liu Jie Tang |
| Affiliation: | a Institute of Drug Design and Development, East China Normal University, Shanghai 200062, China b Department of Chemistry, East China Normal University, Shanghai 200062, China c Reata Pharmaceuticals, Inc. 2801 Gateway Drive, Suite 150, Irving, TX 75063, USA |
| Abstract: | 3-Aryl quinolines are readily synthesized by a novel Friedländer-type reaction with 3-oxo-2,3-diaryl-propionaldehydes and 2-amino arylaldehydes. A preliminary mechanism of this novel one pot, two-step synthesis has been explored with the proofs of isolation of the enaminone intermediate and the eliminated benzoic acid in this reaction. |
| Keywords: | Novel Friedlä nder-type reaction 3-Aryl quinolines Enaminone 3-oxo-2,3-diaryl-propionaldehydes |
| 本文献已被 ScienceDirect 等数据库收录！ | |