Nickel chloride-catalyzed one-pot three-component synthesis of pyrazolophthalazinyl spirooxindoles |
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| Authors: | Xiao-Nan ZhangYong-Xiao Li Zhan-Hui Zhang |
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| Affiliation: | The College of Chemistry and Material Science, Hebei Normal University, Shijiazhuang 050016, China |
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| Abstract: | A direct and efficient approach for the preparation of pyrazolophthalazinyl spirooxindoles has been developed through one-pot three-component reaction of easily available isatin, malononitrile or cyanoacetic ester, and phthalhydrazide catalyzed by nickel chloride in polyethylene glycol 600. Desired products were obtained in high to excellent yields using a simple workup procedure. |
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| Keywords: | Nickel chloride Pyrazolophthalazinyl spirooxindoles Multicomponent reaction One-pot Polyethylene glycol |
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