| 扬州血卟啉衍生物(YHPD)抗癌的分子机理的Raman光谱研究 |
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| 引用本文： | 许以明. 扬州血卟啉衍生物(YHPD)抗癌的分子机理的Raman光谱研究[J]. 光散射学报, 2004, 16(3): 189-198 |
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| 作者姓名： | 许以明 |
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| 作者单位： | 中国科学院生物物理研究所,北京,100101 |
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| 摘 要： | 为探讨卟啉类光敏药物抗癌的分子机理,我们用拉曼光谱研究和比较了YHPD和PhotofrinⅡ对DNA空间结构的微观光敏损伤,又研究了YHPD对蛋白质空间结构的微观光敏损伤。随着研究的深入,我们还从分子水平研究了YHPD和PhotofrinⅡ的3个主要活性组分:HP,PP和DHE对DNA和蛋白质的光敏杀伤特征,以便了解它们在上述光敏药物抗癌中扮演的角色。
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| 关 键 词： | 扬州血卟啉的衍生物 抗癌 Raman光谱 |
| 文章编号： | 1004-5929(2004)03-0189-10 |
| 收稿时间： | 2003-07-21 |
| 修稿时间： | 2003-07-21 |
Raman Spactroscopyic Study of Anticancer Molecule Mechanisms of Yangzhou Hematoporphyrin Derivtive(YHPD) |
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| XU Yi-ming. Raman Spactroscopyic Study of Anticancer Molecule Mechanisms of Yangzhou Hematoporphyrin Derivtive(YHPD)[J]. Chinese Journal of Light Scattering, 2004, 16(3): 189-198 |
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| Authors: | XU Yi-ming |
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| Abstract: | In these works, using laser Raman spectroscopy, photodamage of the space structure of calf thymus DNA sensitized by YHPD and Photofrin Ⅱ was studied and compared. And that of the protein sensitized by YHPD was also researched. Then,characteristics of photosensitive killing on main and active componentes (PP, HP and DHE)* of porphyrin's drugs-YHPD and Photofrin Ⅱ to DNA and protein were studied at the molecular level for understanding the anticancer mechanisms of YHPD and what roles three components play. |
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| Keywords: | YHPD anticancer Raman spectrscopy*PP protoporphyrin HP hematoporphyrin DHE dihematoprophyrin ether and/or ester |
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