Hydroxyl radical generation via photoreduction of a simple pyridine N-oxide by an NADH analogue |
| |
Authors: | Nakanishi Ikuo Nishizawa Chiho Ohkubo Kei Takeshita Keizo Suzuki Kazuo T Ozawa Toshihiko Hecht Sidney M Tanno Masayuki Sueyoshi Shoko Miyata Naoki Okuda Haruhiro Fukuzumi Shunichi Ikota Nobuo Fukuhara Kiyoshi |
| |
Institution: | Redox Regulation Research Group, Research Center for Radiation Safety, National Institute of Radiological Sciences (NIRS), Inage-ku, Chiba, 263-8555, Japan. nakanis@nirs.go.jp |
| |
Abstract: | Photoreduction of pyridine N-oxide, which has a key structure of antitumor agents for hypoxic solid tumors, by 1-benzyl-1,4-dihydronicotinamide in deaerated aprotic media resulted in generation of hydroxyl radical, leading to the oxidation of salicylic acid to 2,3- and 2,5-dihydroxybenzoic acids, and catechol. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|