Alkylated chitosans of low molecular weight as non-viral transfection vectors for gene therapy |
| |
| Authors: | Xin Zhang S. Ercelen V. E. Tikhonov S. Z. Karaeva A. V. Slita V. V. Zarubaev Y. Mély G. Duportail V. G. Babak |
| |
| Affiliation: | (1) A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28, Vavilova str., 117813 Moscow,, Russian Federation;(2) Laboratory of Polymeric Physico Chemistry (LPCP, UMR 5067, IPREM FR 2606), University of Pau and Pays de l’Adour, Helioparc Pyrenees, 2 Avenue President Angot, 64053 Pau, cedex 09, France; |
| |
| Abstract: | Low molecular weight chitosans (5 kDa) hydrophobically modified with 3, 10, and 18 mol % of tetradecenoyl (TDC) groups have been synthesized. Their good solubility at neutral pH, their surface activity and micelle-forming properties as well as their ability to interact with negatively charged phospholipid vesicles mimicking the internal layer of cell plasma membranes, allow us to consider them as potential non-viral transfection vectors for gene therapy. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
