Alkylated chitosans of low molecular weight as non-viral transfection vectors for gene therapy |
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| Authors: | Xin Zhang S Ercelen V E Tikhonov S Z Karaeva A V Slita V V Zarubaev Y Mély G Duportail V G Babak |
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| Institution: | (1) A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28, Vavilova str., 117813 Moscow,, Russian Federation;(2) Laboratory of Polymeric Physico Chemistry (LPCP, UMR 5067, IPREM FR 2606), University of Pau and Pays de l’Adour, Helioparc Pyrenees, 2 Avenue President Angot, 64053 Pau, cedex 09, France; |
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| Abstract: | Low molecular weight chitosans (5 kDa) hydrophobically modified with 3, 10, and 18 mol % of tetradecenoyl (TDC) groups have been synthesized. Their good solubility at neutral pH, their surface activity and micelle-forming properties as well as their ability to interact with negatively charged phospholipid vesicles mimicking the internal layer of cell plasma membranes, allow us to consider them as potential non-viral transfection vectors for gene therapy. |
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