Imaging Sequences for Hyperpolarized Solids |
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| Authors: | Xudong Lv Jeffrey Walton Emanuel Druga Raffi Nazaryan Haiyan Mao Alexander Pines Ashok Ajoy Jeffrey Reimer |
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| Affiliation: | 1.Department of Chemistry, University of California, Berkeley, CA 94720, USA; (X.L.); (E.D.); (R.N.); (A.P.); (A.A.);2.Nuclear Magnetic Resonance Facility, University of California Davis, Davis, CA 95616, USA;3.Department of Chemical and Biomolecular Engineering, University of California, Berkeley, CA 94720, USA;4.Lawrence Berkeley National Laboratory, Materials Science Division, University of California, Berkeley, CA 94720, USA |
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| Abstract: | Hyperpolarization is one of the approaches to enhance Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI) signal by increasing the population difference between the nuclear spin states. Imaging hyperpolarized solids opens up extensive possibilities, yet is challenging to perform. The highly populated state is normally not replenishable to the initial polarization level by spin-lattice relaxation, which regular MRI sequences rely on. This makes it necessary to carefully “budget” the polarization to optimize the image quality. In this paper, we present a theoretical framework to address such challenge under the assumption of either variable flip angles or a constant flip angle. In addition, we analyze the gradient arrangement to perform fast imaging to overcome intrinsic short decoherence in solids. Hyperpolarized diamonds imaging is demonstrated as a prototypical platform to test the theory. |
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| Keywords: | hyperpolarization magnetic resonance imaging flip angle |
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