Synthesis of Quaternary and Tertiary Carbon-Substituted Arenes by Lewis Base Promoted Site-Selective Coupling with Allylic Nucleophiles |
| |
| Authors: | Hawa Keita Prof Simon J Meek |
| |
| Institution: | Department of Chemistry, University of North Carolina at Chapel Hill, 27599-3290 Chapel Hill, NC, USA |
| |
| Abstract: | A practical method for the preparation of quaternary and tertiary allyl-substituted heteroarenes by site-selective couplings of heteroaryl nitriles and allylic nucleophiles is disclosed. Transformations utilize readily accessible stable reagents, proceed in the presence of a Lewis base activator, and undergo aryl-C(sp3) quaternary and tertiary carbon formation with high γ-selectivity (up to >98 : 2 γ : α). |
| |
| Keywords: | Allylation Arene Coupling Heterocycle Organoboron Quaternary Carbon |
|
