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Blending Low-Frequency Vibrations and Push–Pull Effects Affords Superior Photoacoustic Imaging Agents |
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| Authors: | Le Yu Syed Ali Abbas Abedi Dr Jeongjin Lee Yunjie Xu Dr Subin Son Prof Weijie Chi Prof Mingle Li Prof Xiaogang Liu Prof Jae Hyung Park Prof Jong Seung Kim |
| Institution: | 1. Department of Chemistry, Korea University, 02841 Seoul, Republic of Korea
These authors contributed equally to this work.;2. Fluorescence Research Group, Singapore University of Technology and Design, 487372 Singapore, Singapore These authors contributed equally to this work.;3. Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, 06355 Seoul, Republic of Korea These authors contributed equally to this work.;4. Department of Chemistry, Korea University, 02841 Seoul, Republic of Korea;5. Fluorescence Research Group, Singapore University of Technology and Design, 487372 Singapore, Singapore Department of Chemistry, School of Science, Hainan University, 570228 Haikou, China;6. Fluorescence Research Group, Singapore University of Technology and Design, 487372 Singapore, Singapore;7. Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, 06355 Seoul, Republic of Korea |
| Abstract: | Photoacoustic imaging (PAI), a state-of-the-art noninvasive in vivo imaging technique, has been widely used in clinical disease diagnosis. However, the design of high-performance PAI agents with three key characteristics, i.e., near-infrared (NIR) absorption (λabs>800 nm), intense PA signals, and excellent photostability, remains a challenging goal. Herein, we present a facile but effective approach for engineering PAI agents by amplifying intramolecular low-frequency vibrations and enhancing the push-pull effect. As a demonstration of this blended approach, we constructed a PAI agent ( BDP1-NEt2 ) based on the boron-dipyrromethene (BODIPY) scaffold. Compared with indocyanine green (ICG, an FDA-approved organic dye widely utilized in PAI studies; λabs=788 nm), BDP1-NEt2 exhibited a UV/Vis-NIR spectrum peaked at 825 nm, superior in vivo PA signal intensity and outstanding stability to offer improved tumor diagnostics. We believe this work provides a promising strategy to develop the next generation of PAI agents. |
| Keywords: | Acoustogenic Agent Low-Frequency Vibrations Photoacoustic Imaging Push-Pull Effects In Vivo Imaging |