Gold-Catalyzed Amine Cascade Addition to Diyne-Ene: Enantioselective Synthesis of 1,2-Dihydropyridines |
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| Authors: | Jingwen Wei Dr. Yangyang Xing Dr. Xiaohan Ye Bao Nguyen Dr. Lukasz Wojtas Prof. Dr. Xin Hong Prof. Dr. Xiaodong Shi |
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| Affiliation: | 1. Department of Chemistry, University of South Florida, FL 33620 Tampa, USA;2. Center of Chemistry for Frontier Technologies, Department of Chemistry, Zhejiang University, 310027 Hangzhou, China |
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| Abstract: | With the well-documented chemical and biological applications, piperidine and pyridine are among the most important N-heterocycles, and a new synthetic strategy, especially one with an alternative bond-forming design, is of general interest. Using the gold-catalyzed intermolecular condensation of amine and diyne-ene, we report herein the first example of enantioselective 1,2-dihydropyridine synthesis through a formal [3+2+1] fashion (up to 95 % yield, up to 99 % e.e.). |
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| Keywords: | Dihydropyridine Diyne-Ene Enantioselective Gold Catalysis |
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