Coating of finely dispersed particles by two-fluid nozzle |
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| Institution: | 1. Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China;2. State Key Laboratory of Chemical Engineering (Tianjin University), Tianjin 300072, China;1. Faculty of Pharmacy, University of Ljubljana, A?ker?eva 7, 1000 Ljubljana, Slovenia;2. Institute of Pharmaceutics and Biopharmaceutics, Heinrich Heine University, Universitätstr. 1, 40225 Düsseldorf, Germany;1. Department of Chemistry and Chemical Engineering, Chalmers University of Technology, SE-412 96, Göteborg, Sweden;2. Department of Applied Mechanics, Chalmers University of Technology, SE-412 96, Göteborg, Sweden;1. Key Laboratory of Coal Gasification and Energy Chemical Engineering of the Ministry of Education, Shanghai Engineering Research Center of Coal Gasification, Institute of Clean Coal Technology, East China University of Science and Technology, Shanghai 200237, China;2. Dipartimento di Ingegneria Industriale, Università degli Studi di Salerno, Via Giovanni Paolo II, 132, I-84084 Fisciano, SA, Italy;1. Department of Chemical Engineering, College of Engineering, Bharati Vidyapeeth Deemed University, Pune 411 043, India;2. Department of Biotechnology and Chemical Technology, School of Chemical Technology, Alto University, P.O. Box 16100, FI-00076 Aalto, Finland;3. Department of Chemical Engineering, City College of New York, CUNY, NY, USA |
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| Abstract: | Particle coatings are used extensively to generate dispersed solids with well-defined properties, e.g., to protect active ingredients, with most coating processes using core particles of a diameter larger than 200 μm. This work contributes to the development of a coating process for fine dispersed particles (diameter less than 50 μm) by combining two particle-formulation processes, namely, coating and spray drying. The feasibility of the operation is based on and demonstrated by the innovative application of a two-fluid nozzle. Experiments were conducted by using glass particles as core particles and sodium benzoate as the coating agent. The coating of finely dispersed particles is achieved by the spraying of particles and coating solution as a homogeneous suspension. The aim is to create droplets with only one contained particle at the nozzle outlet. After evaporation of the water in the droplet, a thin solid film is built on the particle surface. The suspension viscosity was measured and compared with empirical equations from the literature. The liquid-film thickness on the particle surface was calculated to predict the building of a uniform coating layer or agglomerates. In this study, the feasibility of pneumatic transport through the nozzle and an investigation of the process were illustrated. The agglomeration fraction and degree of coating of the particle surface were analyzed optically by scanning electron microscopy. In this way, the influence of different processes and suspension parameters on the product quality were determined. |
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| Keywords: | Coating Spray drying Fine dispersed particle Two-fluid nozzle |
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