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In Vivo Metabolic Imaging of [1-13C]Pyruvate-d3 Hyperpolarized By Reversible Exchange With Parahydrogen**
Authors:Henri de Maissin  Philipp R. Groß  Obaid Mohiuddin  Dr. Moritz Weigt  Luca Nagel  Marvin Herzog  Zirun Wang  Robert Willing  Dr. Wilfried Reichardt  Dr. Martin Pichotka  Dr. Lisa Heß  Prof. Dr. Thomas Reinheckel  Prof. Dr. Henning J. Jessen  Prof. Dr. Robert Zeiser  Prof. Dr. Michael Bock  Prof. Dominik von Elverfeldt  Prof. Dr. Maxim Zaitsev  Dr. Sergey Korchak  Dr. Stefan Glöggler  Prof. Dr. Jan-Bernd Hövener  Prof. Dr. Eduard Y. Chekmenev  Prof. Dr. Franz Schilling  Dr. Stephan Knecht  Dr. Andreas B. Schmidt
Affiliation:1. Division of Medical Physics, Department of Radiology, Medical Center, Faculty of Medicine, University of Freiburg, Killianstr. 5a, 79106 Freiburg, Germany;2. Division of Medical Physics, Department of Radiology, Medical Center, Faculty of Medicine, University of Freiburg, Killianstr. 5a, 79106 Freiburg, Germany

]Co-first authors.;3. Department of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany;4. Institute of Molecular Medicine and Cell Research, Faculty of Medicine, University of Freiburg, Stefan-Meier-Str. 17, 79104 Freiburg, Germany;5. German Cancer Consortium (DKTK), partner site Freiburg and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany;6. Bioorganic Chemistry, Institute of Organic Chemistry, Albert-Ludwigs-University of Freiburg, Albertstrasse 21, 79104 Freiburg, Germany;7. NMR Signal Enhancement Group, Max Planck Institute for Multidisciplinary Sciences, Am Fassberg 11, 37077 Göttingen, Germany

Center for Biostructural Imaging of Neurodegeneration of the University Medical Center Göttingen, Von-Siebold-Str. 3 A, 37075 Göttigen, Germany;8. Section Biomedical Imaging SBMI, Molecular Imaging North Competence Center MOINCC, Department of Radiology and Neuroradiology, University Hospital Schleswig-Holstein, Kiel University, 24105 Kiel, Germany;9. Department of Chemistry, Integrative Biosciences (Ibio), Karmanos CancerInstitute (KCI), Wayne State University, Detroit, MI 48202 USA;10. NVision Imaging Technologies GmbH, 89081 Ulm, Germany

Abstract:
Keywords:Hyperpolarization  Metabolic Imaging  Parahydrogen  Pyruvate  SABRE
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