| Synthesis of an Anti-1,3-Diol Type Chiral Building Block |
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| 作者姓名： | Yong Wu and |
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| 作者单位： | Yong Wu and (School of Pharmacy，West China University of Medical Sciences，Chengdu，610041) Mei GUAN(The First Hospital，West China University of Medical Sciences，Chengdu，610041) |
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| 摘 要： | Duringthelastdecade,1,3-dioltypechiralbuildingbIocksofvariousconfigurationshavebeensynthesizedandappliedwidelyinthetotalsynthesisofnaturalpolyenemacrolideantibiotics1'2andla,25-dihydroxyvitaminD3analogues'.RecentlyWeigandandBrucker4synthesizedachiralbuildingblock(4R,6R)-2,2-dimethyl-5-tert-butyldip4-hydroxymethyl-l,3-dioxane1inlOsteps.Herein,wereportasyntheticrouteofnewbuildingblock(4S,6S)-2,2-dimethyl-5-tert-butyldip2,anenantiomerofl,startingfromreadilyavailableandinexpensiveD( )-xylose3i…
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Synthesis of an Anti-1,3-Diol Type Chiral Building Block |
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| Yong Wu and.Synthesis of an Anti-1,3-Diol Type Chiral Building Block[J].Chinese Chemical Letters,1998(11). |
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| Authors: | Yong Wu and |
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| Abstract: | A chiral building block, anti-1,3-diol 2, has been synthesized in 7 steps, starting from readily available and inexpensive D-( )-xylose. |
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| Keywords: | Chiral building block anti-1 3-Diol D( )-xylose |
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