Antitrypanosomal activity of a novel norlignan purified from Nectandra lineata |
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| Authors: | Chérigo Lilia Polanco Venancio Ortega-Barria Eduardo Heller Maria V Capson Todd L Rios Luis Cubilla |
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| Affiliation: | Laboratory of Natural Products, Faculty of Natural and Exact Sciences and Technology Apdo. 0824, University of Panama, Panama City, Republic of Panama. |
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| Abstract: | Bioactivity-guided fractionation of a MeOH-EtOAc extract from the young leaves of Nectandra lineata (Lauraceae), using a Trypanosoma cruzi bioassay resulted in the isolation of a novel norlignan 3'-methoxy-3,4-methylenedioxy-4',7-epoxy-9-nor-8,5'-neolignan-9'-acetoxy (1), together with the known compound, 3'-methoxy-3,4-methylenedioxy-4'-7-epoxy-9-nor-8,5'-neolignan-7,8'-diene (2). Compounds 1 and 2 were shown to inhibit the growth of T. cruzi epimastigotes in axenic culture. |
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