Bromine-containing alkaloids from the marine sponge Penares sp. |
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| Authors: | Ekaterina G. LyakhovaSophia A. Kolesnikova Anatoly I. KalinovskyShamil Sh. Afiyatullov Sergey A. DyshlovoyVladimir B. Krasokhin Chau V. MinhValentin A. Stonik |
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| Affiliation: | a G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences, Prospect 100-let Vladivostoku 159, Vladivostok 690022, Russia
b Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam |
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| Abstract: | Two new unusual alkaloids were isolated from the sponge Penares sp., collected from Viet Nam waters (the South China Sea). The structures of these compounds were established by analysis of 1D, 2D NMR (1H-1H COSY, DEPT, HSQC, HMBC, H2BC, and NOE), and MS data. Compound 1 shows moderate cytotoxicity against the human tumor cells HL-60 and HeLa. |
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| Keywords: | Marine alkaloids Sponge Penares sp. Carbazole Indolophenanthridine Tumor cells |
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