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Introducing lasso peptides as molecular scaffolds for drug design: engineering of an integrin antagonist
Authors:Knappe Thomas A  Manzenrieder Florian  Mas-Moruno Carlos  Linne Uwe  Sasse Florenz  Kessler Horst  Xie Xiulan  Marahiel Mohamed A
Affiliation:1. Department of Chemistry/Biochemistry, Philipps‐Universit?t Marburg, Hans‐Meerwein‐Strasse, 35032 Marburg (Germany);2. Institute for Advanced Study and Center for Integrated Protein Science, TU München (Germany);3. Department of Chemical Biology, Helmholtz Centre for Infection Research, Braunschweig (Germany);4. Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah (Saudi Arabia)
Abstract:
Keywords:drug design  epitope grafting  integrin inhibitors  lasso peptides  molecular scaffolds
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