First substoichiometric version of the catalytic enantioselective addition of an alkyllithium to an aldehyde |
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| Authors: | Lecachey Baptiste Fressigné Catherine Oulyadi Hassan Harrison-Marchand Anne Maddaluno Jacques |
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| Institution: | CNRS UMR 6014 & FR 3038, Université de Rouen and INSA de Rouen, Mont St Aignan, France. |
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| Abstract: | A substoichiometric enantioselective version of the extremely fast nucleophilic addition of Alk-Li to RCHO is made possible thanks to a thorough analysis of the aggregation phenomena involved in the reaction: calculated quantities of LiCl must be added to the medium at the right time to keep the catalytic cycle running. |
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