A novel method of preparing amine-modifying C-4' oxidized nucleotide |
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| Authors: | Aso M Ryuo K Kondo M Suemune H |
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| Affiliation: | Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan. aso@phar.kyushu-u.ac.jp |
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| Abstract: | A novel method of preparing C-4' oxidized nucleotide, a monomeric model of an alkali labile lesion (1) has been studied. The C-4' selenated 4a and 4b were found to be effective in preparing 3, a monomeric model of 1, by the reaction with NBS (N-bromosuccinimide). The successive reaction of 3 with amine at room temperature afforded the alpha,beta-unsaturated gamma-methylene-gamma-lactam (2) in good yield. |
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