A short synthesis of bicyclic dipeptides corresponding to Xxx-L-Pro Xxx-D-Pro having constrained trans-proline amides |
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| Authors: | Curran T P Marcaurelle L A O'Sullivan K M |
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| Institution: | Department of Chemistry, College of the Holy Cross, Worcester, Massachusetts 01610-2395, USA. tcurran@holycross.edu |
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| Abstract: | formula: see text] A short synthesis that generates two isomeric bicyclic dipeptides having constrained, trans-proline amide bonds has been developed. One of these bicyclic dipeptides corresponds to an Xxx-L-Pro dipeptide (4), while the other isomer corresponds to an Xxx-D-Pro dipeptide (5). The two isomers are readily distinguished by their 1H NMR spectra. |
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