An efficient procedure for the synthesis of Esomeprazole using a titanium complex with two chiral ligands |
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| Authors: | T. M. Khomenko K. P. Volcho N. I. Komarova N. F. Salakhutdinov |
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| Affiliation: | (1) Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division, Russian Academy of Sciences, pr. Akademika Lavrent’eva 9, Novosibirsk, 630090, Russia |
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| Abstract: | A procedure has been proposed for the selective preparation of Esomeprazole via asymmetric oxidation of the corresponding prochiral sulfide in the presence of a catalytic complex derived from titanium(IV) isopropoxide and two different chiral ligands, diethyl d-tartrate and (R)-N,N-dimethyl-1-phenyl-ethanamine. |
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