Drug loading in cyclodextrin polymers: dexamethasone model drug |
| |
Authors: | Maria D Moya-Ortega Martin Messner Phatsawee Jansook Thorbj?rn Terndrup Nielsen Veronique Wintgens Kim Lambertsen Larsen Catherine Amiel H??kon H Sigurdsson Thorsteinn Loftsson |
| |
Institution: | 1. Faculty of Pharmaceutical Sciences, University of Iceland, Hofsvallagata 53, 107, Reykjavik, Iceland 2. Section of Chemistry, Department of Biotechnology, Chemistry and Environmental Engineering, Aalborg University, Sohngaardsholmsvej 57, 9000, Aalborg, Denmark 3. Laboratoire de Recherche sur les Polym??res, LRP, CNRS, UMR 7581, 2-8 Rue Henri Dunant, 94320, Thiais, France
|
| |
Abstract: | In pharmaceutical formulations cyclodextrins (CDs) are used to improve the aqueous solubility, stability, dissolution rate, bioavailability and/or local tolerance of drugs. Moreover, water-soluble polymers can be used to stabilize drug/CD complexes through formation ternary complexes. Alternative approach is to use CD-polymers, which can both enhance the aqueous solubility of a drug and result in sustained drug release. The aim of this work was to compare the solubilizing effects of ternary drug/CD/polymer complexes with two novel high molecular weight CD-polymers, i.e. poly(ethylene glycol) based ??-cyclodextrin (??CD) polymer (PEG/??CD) and epichlorohydrin-??-cyclodextrin polymer (EPI/??CD) using dexamethasone (Dex) as a model drug, as well as the drug loading capacity of those selected CD-polymers. Hydroxypropyl methylcellulose and carboxymethylcellulose sodium salt were shown to have negligible effect on the solubilizing efficacy of ??CD while hexadimethrine bromide increases the solubilization efficacy. The stability of the polymers was tested and it was adequate for the experimental conditions used. The solubilization efficacy of both CD-polymers was higher than that of the parent ??CD and these ??CD based polymers are able to load greater amount of Dex than the parent ??CD. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|