A simple and efficient route to the FKBP-binding domain from rapamycin |
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| Authors: | Li Wei Bhat Shridhar Liu Jun O |
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| Institution: | a Department of Pharmacology, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
b Department of Oncology, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA |
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| Abstract: | A simple and highly efficient route to the FKBP-binding domain (FKBD) from the natural product rapamycin has been developed, which entails a sequence of ozonolysis/Baeyer-Villiger/Wittig reactions. The newly synthesized FKBD may serve as a core to assemble hybrid macrocyclic libraries for the discovery of novel probes of protein function and to synthesize new ligands for the FKBP family of proteins. |
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| Keywords: | FKBP Rapamycin FKBP-binding domain |
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