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Ozonolysis of phospholipid double bonds during electrospray ionization: a new tool for structure determination
Authors:Thomas Michael C  Mitchell Todd W  Blanksby Stephen J
Institution:Departments of Chemistry and Biomedical Science, University of Wollongong, Wollongong, New South Wales 2522, Australia.
Abstract:Ozonolysis of double bonds is observed during the negative ion electrospray ionization of unsaturated phospholipids under conditions that produce a corona discharge. Ionic products of the ozonolysis are detected and characterized by mass spectrometry, and the mass-to-charge ratio of these species can be used to unambiguously assign the double bond position within the unsaturated fatty acid radyls. The reaction products are consistent with the gas-phase ozonolysis of desolvated phospholipid ions in an atmosphere rich in volatilized solvent. Reactions may be carried out in a conventional electrospray ionization mass spectrometer and provide a new method for the structural characterization of phospholipids.
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