具有生物活性的4-色满酮衍生物的合成进展

4-色满酮衍生物在自然界中广泛存在,大多数都具有生物活性。具有生物活性的4-色满酮衍生物又大多具有手性,尤其C2位置。有关它们的不对称合成引起了有机合成工作者的广泛关注。C2(手性)-4-色满酮衍生物合成的关键是C2手性中心的控制合成。本文根据4-色满酮衍生物构建方式的不同进行分类,概述了近十几年来合成C2(消旋或手性)4-色满酮衍生物的最新方法, 侧重讨论了合成立体结构专一的C2(手性)-4-色满酮的反应特点。

Progress in the Synthesis of 4-Chromanone Derivatives with Bioactivity

4-Chromanone derivatives are widespread in nature, most of which have bioactivities. 4-chromanone derivatives with bioactivities are chiral compounds, especially C2. Their asymmetric syntheses have been attracting great attention. The key step of synthesizing of 4-chromanone derivatives is to control the synthesis of C2 chiral center. In this paper, based on the different ways of synthesizing 4-chromanone derivatives, various methods of controlling C2 (racemic or chiral)-4-chromanone derivatives in recent years were summarized, especially focus on discussing the reaction characteristics of synthesizing C2 (chiral) -4-chromanone derivatives.