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Synthesis, crystal structure and in vitro antibacterial activity of two novel silver(I) complexes |
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| Authors: | Banfeng Ruan Yupeng Tian Hongping Zhou Jieying Wu Chenhao Zhu Hailiang Zhu |
| Institution: | a Department of Chemistry, Key Laboratory of Inorganic Materials Chemistry of Anhui Province, Anhui University, Hefei 230039, PR China b State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China c The State key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, PR China d State Key Laboratory of Crystal Materials, Shandong University, Jinan 250100, PR China |
| Abstract: | Two silver(I) complexes Ag2(dppm)2(L1)2(CH2Cl2)2] (1) and Ag4(dppm)2(L2)2(NO3)2] (2) have been prepared by the reactions of Ag2(dppm)2(NO3)2] with HL1 and HL2 dppm = bis(diphenylphosphino)methane, HL1 = 2-(9H-carbazol-9-yl) acetic acid and HL2 = (E)-3-(4-(9H-carbazole-9-yl) phenyl) acrylic acid], respectively. Both complexes have been structurally characterized by X-ray crystallography, confirming that 1 is a binuclear complex whereas 2 is a tetranuclear one. Both complexes were assayed for antibacterial activity against two Gram-positive bacterial strains (Bacillus subtilis ATCC 6633 and Staphylococcus aureus ATCC 6538) and two Gram-negative bacterial strains (Pseudomonas aeruginosa ATCC 13525 and Escherichia coli ATCC 35218) by MTT method. Complex 2 exhibited powerful antibacterial activities against B. subtilis ATCC 6633 with MIC of 0.78 μg/mL, which was superior to the positive controls penicillin G. On the basis of the biological results, structure-activity relationships were discussed. |
| Keywords: | Antimicrobial drug Silver(I) complex Single crystal diffraction Antibacterial activity |
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