Activation of trimethylsilyl cyanide by potassium phthalimide for facile synthesis of TMS-protected cyanohydrins |
| |
| Authors: | Mohammad G. Dekamin Zahra Karimi |
| |
| Affiliation: | College of Chemistry, Iran University of Science and Technology, Resalat Square, Narmak, Tehran 16846-13114, Iran |
| |
| Abstract: | Potassium phthalimide was found to be a highly effective and easily accessible organocatalyst for the cyanosilylation of various carbonyl compounds under extremely mild conditions. The corresponding cyanohydrin trimethylsilyl ethers were obtained in high to quantitative yields in solvent-free conditions at room temperature using 2.5 mol% catalyst loading. |
| |
| Keywords: | Carbonyl compounds Cyanosilylation Potassium phthalimide Trimethylsilyl cyanide Organocatalysis Solvent-free synthesis |
| 本文献已被 ScienceDirect 等数据库收录！ |
