A Novel 9.4 Tesla FTICR Mass Spectrometer with Improved Sensitivity,Mass Resolution,and Mass Range |
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Authors: | Nathan K Kaiser John P Quinn Gregory T Blakney Christopher L Hendrickson Alan G Marshall |
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Institution: | (1) Ion Cyclotron Resonance Program, National High Magnetic Field Laboratory, Florida State University, 1800 East Paul Dirac Dr., Tallahassee, FL 32310, USA;(2) Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306, USA; |
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Abstract: | Fourier transform ion cyclotron resonance (FTICR) mass spectrometry provides unparalleled mass measurement accuracy and resolving
power. However, propagation of the technique into new analytical fields requires continued advances in instrument speed and
sensitivity. Here, we describe a substantial redesign of our custom-built 9.4 tesla FTICR mass spectrometer that improves
sensitivity, acquisition speed, and provides an optimized platform for future instrumentation development. The instrument
was designed around custom vacuum chambers for improved ion optical alignment, minimized distance from the external ion trap
to magnetic field center, and high conductance for effective differential pumping. The length of the transfer optics is 30%
shorter than the prior system, for reduced time-of-flight mass discrimination and increased ion transmission and trapping
efficiency at the ICR cell. The ICR cell, electrical vacuum feedthroughs, and cabling have been improved to reduce the detection
circuit capacitance (and improve detection sensitivity) 2-fold. The design simplifies access to the ICR cell, and the modular
vacuum flange accommodates new ICR cell technology, including linearized excitation, high surface area detection, and tunable
electrostatic trapping potential. |
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