Capillary electrophoresis time-of-flight mass spectrometry of an opium powder |
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Authors: | I M Lazar G Naisbitt M L Lee |
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Institution: | (1) Department of Chemistry and Biochemistry, Brigham Young University, 84602-5700 Provo, UT, USA;(2) Utah State Crime Laboratory, 84114-8285 Salt Lake City, UT, USA |
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Abstract: | Summary Intensive work has been invested in recent years to evaluate the performance of capillary electrophoresis (CE) in forensic
analysis. Tremendous progress has also been achieved in interfacing CE to sensitive and specific detection systems such as
the mass spectrometer (MS). We have recently developed an electrospray time-of-flight mass spectrometer (ESI-TOFMS) for use
as a detector for fast and efficient liquid phase separations. In the present paper we investigated ESI-TOFMS for the analysis
of an opium powder. Both continuous infusion and CE were studied for direct sample introduction into the TOFMS and mixture
separation, respectively. CEMS analysis of the opium was performed in a citrate buffer, using aqueous or mixed aqueous/organic
eluents. Low fmol detection was achieved. |
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Keywords: | Capillary electrophoresis Mass spectrometry Time-of-flight Opium Drugs |
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