Titanium(IV) alkoxide ligand exchange with alpha-hydroxy acids: the enantioselective aldol addition |
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| Authors: | Mahrwald |
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| Institution: | Institut fur Organische und Bioorganische Chemie der Humboldt-Universitat Berlin, Hessische Strasse 1-2, D-10 115 Berlin, Germany. |
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| Abstract: | Ligand exchange of titanium(IV) alkoxides with alpha-hydroxy acids presents an unexpected and novel approach to enantioselective aldol additions of aldehydes and ketones. The aldol products were isolated in a high degree of syn-diastereoselectivity. High enantioselectivities were observed by using simple optically pure alpha-hydroxy acids in this novel aldol addition. |
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