Column asymmetric catalysis for beta-lactam synthesis |
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| Authors: | Hafez A M Taggi A E Wack H Drury W J Lectka T |
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| Affiliation: | Department of Chemistry, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA. |
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| Abstract: | [structure] A catalytic asymmetric reaction process was designed involving the use of solid-phase reagents and catalysts that constitute the packing of a series of "reaction columns". This process was applied to the catalytic asymmetric synthesis of beta-lactams, yielding pure product after crystallization with exceptional enantio- and diastereoselectivity. |
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