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Short enantioselective syntheses of trans-5-alkylprolines from new functionalized amino alcohols
Authors:Alladoum Jeanne  Roland Sylvain  Vrancken Emmanuel  Mangeney Pierre  Kadouri-Puchot Catherine
Affiliation:Université Pierre et Marie Curie-Paris 6, Laboratoire de Chimie Organique UMR 7611, Institut de Chimie Moléculaire FR 2769, 4 place Jussieu, case courrier 47, 75005 Paris, France.
Abstract:Amino alcohols, having an enol ether function, cyclized in acidic medium to give quantitatively diastereosomerically pure bicyclic compounds that were transformed in five steps in enantiopure trans-5-alkylproline derivatives.
Keywords:
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