Le blocage de la lysine par la réaction de MAILLARD. I. Synthèse de N-(désoxy-1-D-fructosyl-1)- et N-(désoxy-1-D-lactulosyl-1)-L-lysines

The authors describe a specific method for the preparation of N?-(1-deoxy-D-fructosyl)-L-lysine, Nα-(1-deoxy-D-fructosyl)-L-lysine, their formyl derivatives, and Nα-formyl-?-(1-deoxy-D-lactulosyl)-L-lysine, as well as Nα, N?-di-(1-deoxy-D-fructosyl)-L-lysine. After purification by cation-exchange chromatography using volatile pyridine-acetic acid or pyridine-formic acid buffers, these compounds are obtained in the pure state. By thin-layer chromatography and paper electrophoresis these lysine derivatives can be rapidly separated and identified.