Use of isothermal microcalorimetry in pharmaceutical preformulation studies,Part II. Amorphous phase quantification in a predominantly crystalline phase |
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Authors: | Murti Vemuri N Chrzan Zofia Cavatur Raghu |
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Institution: | (1) Aventis Pharmaceuticals Route 202/206 S, P.O. BOX 6800, Mail Stop E-103B, Bridgewater, NJ 08807, USA |
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Abstract: | Low amounts of amorphous phase present in predominantly crystalline powders were quantified by using various analytical techniques
with an emphasis on the use of Isothermal Perfusion Microcalorimetry. The amorphous phase was plasticized using ethanol vapor
and enthalpy of re-crystallization of amorphous phase was used for generation of a calibration curve. Amorphous content as
low as 5% was quantified using this technique. Although baseline noise was very low, additional processes occurring during
re-crystallization confounded quantification of lower amorphous fractions.
This revised version was published online in July 2006 with corrections to the Cover Date. |
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Keywords: | differential scanning calorimetry isothermal microcalorimetry quantification amorphous phase powder X-ray diffraction water vapor sorption |
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