Dual-functional probes towards in vivo studies of brain connectivity and plasticity |
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| Authors: | Mamedov Ilgar Engelmann Jörn Eschenko Oxana Beyerlein Michael Logothetis Nikos K |
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| Affiliation: | Department for Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Spemannstr. 38, 72076, Tübingen, Germany. ilgar.mamedov@tuebingen.mpg.de |
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| Abstract: | A Gd(3+) based paramagnetic dextran conjugate has been developed, which enables the tracking of neuroanatomical connectivity in the brain by both MR and optical imaging. Cell studies and subsequent in vivo experiments in rodents demonstrate efficient internalisation and transport properties of the new tracer molecule. |
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