Introducing chemiluminescence resonance energy transfer into immunoassay in a microfluidic format for an improved assay sensitivity |
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| Authors: | Zhao Shulin Liu Jinwen Huang Yong Liu Yi-Ming |
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| Affiliation: | Ministry of Education Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Chemical Engineering, Guangxi Normal University, Guilin, Guangxi 541004, China. zhaoshulin001@163.com |
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| Abstract: | We report on a novel strategy to improve microfluidic immunoassay sensitivity by introducing chemiluminescence resonance energy transfer (CRET) into the immunoreactions. The proposed CRET-based immunoassay for estradiol (E2, as a model analyte) is one of the most sensitive immunoassay with a limit of detection at 3.6 × 10(-11) M E2 in a microfluidic format. |
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