Chemo-enzymatic synthesis of both enantiomers of rugulactone |
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Authors: | Gowrisankar Reddipalli Mallam Venkataiah Nitin W. Fadnavis |
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Affiliation: | Biotransformation Laboratary, Indian Institute of Chemical Technology, Uppal Road, Habsiguda, Hyderabad 500 007, India |
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Abstract: | The synthesis of both the (R)- and (S)-enantiomers of the natural product rugulactone has been achieved. Candida rugosa lipase hydrolyzes the butyrate ester of the protected 3-hydroxy homoallylic alcohol with very high enantioselectivity (E = 244) and provides the key intermediates with high enantiomeric purity (ee 98–99%) and excellent yields. |
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