An efficient synthesis of aziridines from ephedrines |
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| Authors: | Alejandro Cruz Itzia Irene Padilla-Martínez Efrén V García-Báez |
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| Institution: | Departamento de Ciencias Básicas de la Unidad Profesional Interdisciplinaria de Biotecnología del IPN, Av. Acueducto s/n Barrio la Laguna Ticomán, México, D.F. 07340, Mexico |
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| Abstract: | The reaction of chlorodeoxyephedrine hydrochlorides with one, two, and three molar equivalents of base was studied. Isochlorodeoxypseudoepherines were identified and assigned by 1H and 13C NMR data as intermediate compounds in the formation of cis-aziridines. Erythro and threo ephedrinethylethers were isolated as new compounds and analyzed by spectroscopic data. In addition, the erythro isomer was studied by X-ray diffraction. |
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