Chirality control in the enantioselective arylation of aromatic aldehydes catalyzed by cis-(1R,2S)-2-benzamidocyclohexanecarboxylic acid derived 1,3-aminoalcohols |
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| Authors: | Xiang-Bo Wang Koichi Kodama Takuji Hirose Xiao-Feng Yang Guang-You Zhang |
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| Institution: | 1. School of Science and Engineering, Saitama University, 255 Shimo-ohkubo, Sakura, Saitama 338-8570, Japan;2. Department of Chemical Engineering, University of Jinan, 106 Jiwei Road, Jinan, Shandong Province 250022, China |
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| Abstract: | A series of chiral 1,3-aminoalcohols derived from cis-(1R,2S)-2-benzamidocyclohexanecarboxylic acid were synthesized and applied to the enantioselective arylation of aromatic aldehydes. The reactions exhibited good yields (up to 90%) and moderate to high enantioselectivities (up to 99%). Not only the enantioselectivity but also the stereochemistry of the product were controlled by the substituent effect of the chiral ligands. |
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