A practical procedure for the removal of the phenylethanol moiety from phenylglycinol-derived lactams |
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| Authors: | Vladislav Semak Carmen Escolano Carlos Arróniz Joan Bosch Mercedes Amat |
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| Institution: | Laboratory of Organic Chemistry, Faculty of Pharmacy, and Institute of Biomedicine (IBUB), University of Barcelona, 08028 Barcelona, Spain |
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| Abstract: | Chiral non-racemic bicyclic lactams derived from phenylglycinol have been appointed as key building blocks for the preparation of enantiopure nitrogen compounds. The removal of the chiral inductor leading to substituted piperidones by using air or oxygen in basic media is presented. |
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