Enzymatic resolution of racemic secondary cyclic allylic alcohols |
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| Authors: | Katarzyna Wińska Aleksandra Grudniewska Anna Chojnacka Agata Białońska Czesław Wawrzeńczyk |
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| Institution: | 1. Department of Chemistry, Wroc?aw University of Environmental and Life Sciences, Norwida 25, 50-375 Wroc?aw, Poland;2. Faculty of Chemistry, University of Wroc?aw, F. Joliot-Curie 14, 50-383 Wroc?aw, Poland |
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| Abstract: | The resolutions of five racemic cyclic alcohols: 6,6-dimethylcyclohex-2-en-1-ol (±)-5, 4,4-dimethylcyclohex-2-en-1-ol (±)-7, 5,5-dimethylcyclohex-2-en-1-ol (±)-11 and isomeric trans-(±)-13 and cis-piperitols (±)-14 are presented. They were resolved by enzymatic esterification with vinyl esters or by enzymatic hydrolysis of their racemic esters in phosphate buffer. The following lipases were used as biocatalysts: Novozyme 435 (Candida antarctica), Amano PS (Burkholderia cepacia) and lipase from Candida cylindracea. All isomers of alcohols were obtained with at least 96% ee. |
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