Asymmetric synthesis of hydroxy-skipped bishomo-inositols as potential glycosidase inhibitors |
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| Authors: | Tridib Mahapatra Samik Nanda |
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| Affiliation: | Department of Chemistry, Indian Institute of Technology, Kharagpur 721302, India |
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| Abstract: | Four isomeric hydroxy-skipped bishomo-inositol analogs have been synthesized from both enantiomers of 5-hydroxymethyl-2-cyclohexenone. Sharpless asymmetric dihydroxylation and substrate-directed anionic hydroxymethylation are the key reactions which have been employed successfully for the synthesis of new cyclitols. The synthesized cyclitols have been screened for their inhibitory effect on α- and β-glycosidases. |
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