Organocatalyzed synthesis of chiral non-racemic 1,4-dihydropyridazines |
| |
Authors: | Giuliana Pitacco Orazio A Attanasi Lucia De Crescentini Gianfranco Favi Fulvia Felluga Cristina Forzato Fabio Mantellini Patrizia Nitti Ennio Valentin Ennio Zangrando |
| |
Institution: | 1. Dipartimento di Scienze Chimiche, Università di Trieste, Via Licio Giorgieri 1, 34127 Trieste, Italy;2. Istituto di Chimica Organica, Università di Urbino ‘Carlo Bo’, Via I Maggetti 24, 61029 Urbino, Italy |
| |
Abstract: | Chiral non-racemic 1,4-dihydropyridazines were prepared by the reaction of 1,2-diaza-1,3-dienes with arylacetaldehydes under organocatalytic conditions. l-Proline and (S)-(+)-1-(2-pyrrolidinylmethyl)pyrrolidine coupled with trifluoroacetic acid were used as organocatalysts. Enantiomeric excesses ranged from 25% to 78%. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|