首页 | 本学科首页   官方微博 | 高级检索  
     检索      


Stereocontrolled synthesis of enantiopure anticancer cyclopentenone prostaglandin analogues: (?)- and (+)-TEI-9826
Authors:Remigiusz ?urawiński  Maciej Mikina  Marian Miko?ajczyk
Institution:Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Department of Heteroorganic Chemistry, Sienkiewicza 112, 90-363 ?ód?, Poland
Abstract:The synthesis of both enantiomers of TEI-9826 has been accomplished in seven steps with an overall yield of 44% starting from diastereomeric camphor protected 3-(dimethoxyphosphoryl)methyl]-4,5-dihydroxycyclopent-2-enones. The key steps include a fully diastereoselective hydrogenation of the endocyclic carbon–carbon double bond in the cyclopentenone ring controlled with a chiral diol moiety and the conversion of the latter into a new transposed olefinic bond.
Keywords:
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号