The synthesis of (1S,8aS)-1-hydroxyindolizidine using a stereoselective Grignard addition to an N-benzyl-3-deoxy sugar imine derived from D-Glucose |
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| Authors: | Y Jagadeesh B Chandrasekhar B Venkateswara Rao |
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| Institution: | Organic Division III, Indian institute of Chemical Technology, Hyderabad 500 607, India |
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| Abstract: | A highly stereoselective approach to 1-hydroxyindolizidine is described using a Grignard reaction on N-benzyl imine derived from 3-deoxy-1,2-O-isopropylidine-α-d-xylo-pentodialdofuranose and reductive cyclization as key steps. |
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