Highly modular P-OP ligands in asymmetric allylic substitution |
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Authors: | Armen Panossian Héctor Fernández-Pérez Dana Popa Anton Vidal-Ferran |
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Affiliation: | 1. Institute of Chemical Research of Catalonia (ICIQ), Av. Països Catalans 16, 43007 Tarragona, Spain;2. Catalan Institute for Research and Advanced Studies (ICREA), Pg. Lluis Companys 23, 08010 Barcelona, Spain |
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Abstract: | A library of highly modular P-OP ligands have been evaluated in Pd-catalysed allylic substitutions with C- and N-nucleophiles. Catalyst optimisation via a variation of the phosphino and phosphite substituents led to a ‘lead’ catalyst, which efficiently mediated the allylic substitutions when various combinations of substrates and nucleophiles were tested. Ground-state calculations were carried out and these allowed a clearer understanding of the stereochemical outcome of the reaction. |
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