Acid–base organocatalysts for the aza-Morita–Baylis–Hillman reaction of nitroalkenes |
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| Authors: | Shinobu Takizawa Atsushi Horii Hiroaki Sasai |
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| Institution: | The Institute of Scientific and Industrial Research (ISIR), Osaka University, Mihogaoka, Ibaraki, Osaka 567-0047, Japan |
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| Abstract: | A new class of acid–base chiral organocatalysts 1a and 2 for aza-Morita–Baylis–Hillman (aza-MBH) reaction of conjugated nitroalkenes is described. The acidic phenolic hydroxy groups and basic imidazole unit cooperatively activate nitroalkenes to promote the aza-MBH reaction in good yields with moderate enantioselectivities. |
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